Gene was born in Turbigo in Lombardy, and studied at the University of Pavia. He published many works on natural history, especially entomology. In 1828 he became lecturer in natural history at the University the following year he went to Hungary and returned with a collection of insects. Between 1833 and 1838 he made four trips to Sardinia collecting insects.
In 1830 succeeded Franco Andrea Bonelli Gene as a professor of zoology and director of the Royal Zoological Museum at Turin contains a picture of the gene. Most of his insect collection in the Turin Museum of Natural History. Duplicates are in the Museo di Storia Naturale de Milan Civic and Museo di Storia naturale, Pisa.
Slender-billed Gull Larus gene was named after him.
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